Replication of Cortisol Circadian Rhythm

Woman sleeping in her bed.
New Advances in Hydrocortisone Replacement Therapy Summary: Cortisol is essential to life, and is elevated in the morning and decreased at night while being a crucial part of the circadian rhythm. When circadian rhythm (cortisol release) is disrupted, that is associated with increased risk of mortality, sleep disturbances, increased bone turnover, worsening of cardiovascular risk
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Circadian Clock Protein Rev-erbα Regulates Neuroinflammation

X Ray with brain and skull
Summary: The protein Rev-erbα controls brain inflammation, which neuroinflammation has been associated with many diseases including cancer and neurodegeneration. Circadian rhythm disruption leads to the suppression of Rev-erbα, which causes microglial and astrocyte activation, inflammation, and brain injury. Abstract: Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of which are associated with
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Adolescent Changes in Homeostatic and Circadian Regulation of Sleep

You man sleeping with light trickling over his face.
Summary: Adolescents have different sleep cycles because their circadian and homeostatic systems are still developing (this is even across cultures and species). Abstract: Sleep deprivation among adolescents is epidemic. We argue that this sleep deprivation is due in part to pubertal changes in the homeostatic and circadian regulation of sleep. These changes promote a delayed
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Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1

BMAL1 Graphical Abstract
Summary: Sleep disruption (circadian rhythm dysfunction) can influence brain function and neurological diseases through inflammatory pathways. Abstract: Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood. Astrocyte activation occurs in response to diverse insults and plays a critical role in brain health and
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Facts about Melatonin and Sleep

Melatonin-Sleep-Cycle-Circadian
What is Melatonin? Melatonin has recently been in the spot light, mainly helping people with sleep. However, there are health concerns with it particularly people becoming dependent on it to sleep. This blog will synthesize the research surrounding melatonin. A good place to start the talk about whether oral melatonin is good or bad is
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