Circadian Clock Protein Rev-erbα Regulates Neuroinflammation
Wednesday, March 13, 2019
Summary: The protein Rev-erbα controls brain inflammation, which neuroinflammation has been associated with many diseases including cancer and neurodegeneration. Circadian rhythm disruption leads to the suppression of Rev-erbα, which causes microglial and astrocyte activation, inflammation, and brain injury. Abstract: Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of which are associated with
- Published in Scientific Article
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Pro-Resolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammtion
Friday, February 15, 2019
Summary: The fat-soluble omega-3 fatty acid derivatives, Selective Pro-Resolving Mediatiors (SPMs), are critical in the resolution of inflammation, rather than just blocking the inflammatory cascade. Abstract: Inflammatory responses, like all biological cascades, are shaped by a delicate balance between positive and negative feedback loops. It is now clear that in addition to positive and negative
- Published in Scientific Article