Functional Wellness Chiropractic Center
BOOK AN APPOINTMENT BY PHONE
CALL: 608-203-9272

7818 Big Sky Drive, Suite 215
Madison, Wisconsin 53719
  • HOME
  • SERVICES
    • FUNCTIONAL MEDICINE
    • NUTRITION
    • CHIROPRACTIC
    • FULL SERVICES
  • ABOUT US
  • STORE
  • RESOURCES
    • FUNCTIONAL NEWS
    • SCIENTIFIC ARTICLES
    • FORMS
  • CONTACT US
INTAKE FORM(PDF)

Circadian Clock Protein Rev-erbα Regulates Neuroinflammation

by Eric / Wednesday, March 13, 2019 / Published in Scientific Article
X Ray with brain and skull

Summary:

The protein Rev-erbα controls brain inflammation, which neuroinflammation has been associated with many diseases including cancer and neurodegeneration. Circadian rhythm disruption leads to the suppression of Rev-erbα, which causes microglial and astrocyte activation, inflammation, and brain injury.

Abstract:

Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of which are associated with neuroinflammation. Circadian rhythm dysfunction has been associated with inflammation in the periphery, but the role of the core clock in neuroinflammation remains poorly understood. Here we demonstrate that Rev-erbα, a nuclear receptor and circadian clock component, is a mediator of microglial activation and neuroinflammation. We observed time-of-day oscillation in microglial immunoreactivity in the hippocampus, which was disrupted in Rev-erbα−/− mice. Rev-erbα deletion caused spontaneous microglial activation in the hippocampus and increased expression of proinflammatory transcripts, as well as secondary astrogliosis. Transcriptomic analysis of hippocampus from Rev-erbα−/− mice revealed a predominant inflammatory phenotype and suggested dysregulated NF-κB signaling. Primary Rev-erbα−/− microglia exhibited proinflammatory phenotypes and increased basal NF-κB activation. Chromatin immunoprecipitation revealed that Rev-erbα physically interacts with the promoter regions of several NF-κB–related genes in primary microglia. Loss of Rev-erbα in primary astrocytes had no effect on basal activation but did potentiate the inflammatory response to lipopolysaccharide (LPS). In vivo, Rev-erbα−/− mice exhibited enhanced hippocampal neuroinflammatory responses to peripheral LPS injection, while pharmacologic activation of Rev-erbs with the small molecule agonist SR9009 suppressed LPS-induced hippocampal neuroinflammation. Rev-erbα deletion influenced neuronal health, as conditioned media from Rev-erbα–deficient primary glial cultures exacerbated oxidative damage in cultured neurons. Rev-erbα−/− mice also exhibited significantly altered cortical resting-state functional connectivity, similar to that observed in neurodegenerative models. Our results reveal Rev-erbα as a pharmacologically accessible link between the circadian clock and neuroinflammation.

Source:

https://www.pnas.org/content/116/11/5102.short

  • Tweet
Tagged under: Cancer, Circadian, circadian rhythm, Inflammation, sleep

What you can read next

MRI brain scan images
The Calorically Restricted Ketogenic Diet, An Effective Alternative Therapy for Malignant Brain Cancer
Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals
Woman sleeping in her bed.
Replication of Cortisol Circadian Rhythm

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Form may take a few seconds to load - to download directly, click the download link in the bottom left corner.

Loader Loading...
EAD Logo Taking too long?

Reload Reload document
| Open Open in new tab

Download [1.95 MB]

Testimonials

  • "...Our son is a high functioning autistic child with various sensory issues as well. Dr. Eric has helped us find solutions for some of our son's behavior issues through natural supplements and diet control..."

    David Wells

  • "...was told by other chiropractors that I would need to see them 3 times a week for two months to help fix my upper neck pain. I had two appointments with Dr. Eric and I have been pain free ever since..."

    Preslee Steiner

  • "...It's refreshing to have a Chiropractor that is interested in helping me solve my problems instead of getting me back in the office in a few days so they can charge me another fee for 5 minutes of treatment."

    Randy Schmidt

  • "...He [Dr. Eric] is very competent and caring and I feel he is on the cutting edge of wellness and all of its components. I consider myself fortunate to have found him."

    Robert Holmes

  • "...Dr. Johnson was able to address the structural and muscular issues that have contributed to the pain, and with chiropractic adjustments, specific stretches and exercises along with myofascial release therapy by someone recommended by Dr. Johnson, I feel my pain has been reduced by almost 90 percent...."

    Lois Neis

  • "...I felt very comfortable and only saw him 3 times before almost all my pain was gone..."

    Katie Steele

  • "...He really knows what it takes to help feel better and live life to the fullest!"

    Annamaria Bliven

  • "...I was referred to Dr. Eric and after my first visit I had full motion back in my shoulder, after the 2nd visit I had no pain and could throw a golf ball. I highly recommend Dr. Eric..."

    Paul Brooks

  • "...My experience has been nothing short of amazing as I have begun to roll back the effects of 10+ years with a connective tissue autoimmune disorder..."

    Kathleen Harwood

  • "...Just after a few adjustments, I had noticed a huge difference from the way I was feeling. He is truly a caring man and is all about getting the patient better..."

    Lilly Blumer

  • "...He helped me get through a hip injury during my Ironman training and also gave me a list of stretches and exercises to do to prevent it from happening again..."

    Kenny Haferkorn

  • "...I have recommended Dr. Eric to family and friends. I can't thank him enough for his compassion and desire to see that I have the quality of life that I have always wanted."

    Karie Nafzger

Address

7818 Big Sky Dr
Suite 215
Madison, WI 53719

PHONE

608-203-9272

Hours

Monday - Saturday: 9am - 6pm
Other Hours Available by Appointment

Follow Us

© 2019 All rights reserved | Powered by DIGITAL FITNESS | Sitemap |

TOP Cleantalk Pixel