Intestinal Glutathione Synthesis in Patients with IBD

Intestinal glutahione susthesis - antioxidants
Summary: Decreased glutathione (body’s main antioxidant) production and availability in the body means decreased mucosal glutathione, which protects the intestinal lining from oxidative damage. Addressing glutathione deficiency could help with the treatment of irritable bowel disease (IBD). Abstract:  BACKGROUND: Reactive oxygen species contribute to tissue injury in inflammatory bowel disease (IBD). The tripeptide glutathione (GSH)
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Chiropractic Care and Cervical Artery Dissection

cervical artery dissection
Systematic Review and meta-analysis of chiropractic care and cervical artery dissection: no evidence for causation. Summary: There is no convincing evidence that there’s a causal link between chiropractic manipulation and cervical artery dissection (stroke). Studies that show association between the two have high risk of bias. The annual incidence of artery dissection is between 2-3
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How the Lung Environment Controls Alveolar Macrophage Metabolism

Lungs related to alveolar macrophage metabolism
Summary: Glucose (sugar) availability in the lungs could influence the immune response. Abstract: Fine control of macrophage activation is needed to prevent inflammatory disease, particularly at barrier sites such as the lungs. However, the dominant mechanisms that regulate the activation of pulmonary macrophages during inflammation are poorly understood. We found that alveolar macrophages (AlvMs) were
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Low-carb and Low-fat diets in Relation to Knee Osteoarthritis

Female runner suffering with pain on sports running knee injury
Summary: Low-carbohydrate diet reduced pain intensity both subjectively and objectively. It also reduced adipokine leptin and oxidative stress, which could have been the cause of the pain. Abstract: OBJECTIVE: Osteoarthritis is the most prominent form of arthritis, affecting approximately 15% of the population in the United States. Knee osteoarthritis (KOA) has become one of the
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Dietary Fatty Acids and Susceptibility to Multiple Sclerosis

Dietary fatty acids and MS
Summary: Incorporating short chain fatty acids (SCFAs) is a safe and potent add-on therapy for multiple sclerosis (MS). Abstract: BACKGROUND: The gut microbiome as well as dietary habits have recently been established as environmental contributors to the pathogenesis of multiple sclerosis (MS), a T-cell-mediated autoimmune disease of the central nervous system (CNS). OBJECTIVE: To summarize
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SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain

SCFAs train T cells
Summary: Short Chain Fatty Acids (SCFAs) produced by gut bacteria decreases autoimmunity (immune system attacking host tissue) against the brain. Abstract:  In this issue of Immunity, Haghikia and colleagues (2015)demonstrate that dietary fatty acids, by modulating gut microbes and their metabolism, regulate mucosal immune cells to impact systemic immunity. Using this mechanism, dietary and bacteria-derived medium-chain and
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Inflammatory Bowel Disease

IBD - Inflammatory Bowel Disease
Summary: Brain lesions can be a result of inflammatory bowel disease (IBD). Abstract: BACKGROUND: Neurological manifestations in patients with inflammatory bowel disease supposedly are rare, although the exact frequency is not known. Most previous reports involve cerebral venous thrombosis, central nervous system vasculitis, or peripheral nerve inflammation. METHODS: Two cases of patients diagnosed with inflammatory
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Low Back Pain

Young adult woman with back pain
Summary: Improvement during low back pain treatment sessions indicate a 3.5 better chance of improvement in-between sessions. In other words, if there’s improvement during a low back treatment (especially first treatment) then there’s a higher chance there’s going to be continued improvement. Abstract: Physiotherapists commonly use post-treatment changes in a patient’s pain intensity and range
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Efficacy of Low Level Laser Therapy

Laser therapy. Physical therapist treating patient's shoulder
Summary: Low level light therapy (LLLT) has a greater therapeutic effect with pulsed emissions, rather than continuous emissions. Abstract:  Background. There are several studies in the literature regarding the clinical efficacy of Low Level Laser Therapy (LLLT), however the very few randomized, double blind clinical trials available present contrasting views. The purpose of this trial
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The anti-inflammatory mechanism of 635 nm light-emitting diode irradiation.

Summary: Like COX inhibitors (like ibuprofen), red LED’s (light-emitting diodes) with the wavelength of 635 nanometers (nm) inhibited inflammatory markers, proving to be anti-inflammatory. Unlike COX inhibitors, red LED’s decreased reactive oxygen species (ROS), which high levels of ROS is associated to higher cellular damage. Abstract: Background and Objectives Inhibition of cyclooxygenase (COX) and prostaglandin
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