Functional Wellness Chiropractic Center
BOOK AN APPOINTMENT BY PHONE
CALL: 608-203-9272

7818 Big Sky Drive, Suite 215
Madison, Wisconsin 53719
  • HOME
  • SERVICES
    • FUNCTIONAL MEDICINE
    • NUTRITION
    • CHIROPRACTIC
    • FULL SERVICES
  • ABOUT US
  • STORE
  • RESOURCES
    • FUNCTIONAL NEWS
    • SCIENTIFIC ARTICLES
    • FORMS
  • CONTACT US
INTAKE FORM(PDF)

Young Plasma Attenuates Age-Dependent Liver Ischemia Reperfusion Injury.

by Eric / Wednesday, February 20, 2019 / Published in Scientific Article
Drawing Blood for Platelet Rich Plasma

Summary:

Aging is associated with cellular damage and the body’s decreased ability to “clean itself up,” which is known as autophagy. Those associations of aging were reversed when plasma from younger individuals were administered to older individuals through multiple mechanisms, including reoxygenation. Keep in mind, this study was done in rats.

Abstract:

Aging is often associated with a decreased autophagic activity that contributes to the high sensitivity of aged livers to ischemia reperfusion injury (IRI). Blood from young animals can positively affect aged animals. This study was designed to evaluate the effect of young plasma in a model of liver IRI in aged rats. Aged rats were treated with pooled plasma collected from young rats before ischemia. Administration of young plasma restored aging-induced suppression in hepatic autophagic activity and reduced liver IRI. Inhibition of the young-plasma-restored autophagic activity abrogated the beneficial effect of young plasma against liver IRI. Similarly, young serum restored autophagic activity and reduced cellular injury after hypoxia/reoxygenation (H/R) in primary old rat hepatocytes. Mechanistic studies showed thatadministration of young plasma increased AMPK phosphorylation and led to unc-51-like autophagy activating kinase (ULK)1 activation. Furthermore, AMPK-inhibition abrogated the young serum-induced ULK1 activation and autophagic activity and diminished the protective action of young serum against H/R injury in primary old rat hepatocytes, whereas AMPK-activation potentiated the effects of young serum. Young plasma could restore age-impaired autophagy, at least in part, via AMPK/ULK1 signaling. Restoration of age-impaired autophagic activity may be a critical contributing mechanism to young-plasma-afforded protection against liver IRI in aged rats.

-Liu, A., Yang, J., Hu, Q., Dirsch, O., Dahmen, U., Zhang, C., Gewirtz, D. A., Fang, H., Sun, J.

Source:

https://www.ncbi.nlm.nih.gov/pubmed/30383439

  • Tweet
Tagged under: Aging, Autophagy, Live, Oxygen, Plasma

What you can read next

Young woman accountant talking on cell phone and writing
Effects of Cell Phone Radiofrequency Signal Exposure on Brain Glucose Metabolism.
Plate with an apple and measuring tape
Where does the Fat Go?
Female runner suffering with pain on sports running knee injury
Low-carb and Low-fat diets in Relation to Knee Osteoarthritis

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Form may take a few seconds to load - to download directly, click the download link in the bottom left corner.

Loader Loading...
EAD Logo Taking too long?

Reload Reload document
| Open Open in new tab

Download [1.95 MB]

Testimonials

  • "...Our son is a high functioning autistic child with various sensory issues as well. Dr. Eric has helped us find solutions for some of our son's behavior issues through natural supplements and diet control..."

    David Wells

  • "...was told by other chiropractors that I would need to see them 3 times a week for two months to help fix my upper neck pain. I had two appointments with Dr. Eric and I have been pain free ever since..."

    Preslee Steiner

  • "...It's refreshing to have a Chiropractor that is interested in helping me solve my problems instead of getting me back in the office in a few days so they can charge me another fee for 5 minutes of treatment."

    Randy Schmidt

  • "...He [Dr. Eric] is very competent and caring and I feel he is on the cutting edge of wellness and all of its components. I consider myself fortunate to have found him."

    Robert Holmes

  • "...Dr. Johnson was able to address the structural and muscular issues that have contributed to the pain, and with chiropractic adjustments, specific stretches and exercises along with myofascial release therapy by someone recommended by Dr. Johnson, I feel my pain has been reduced by almost 90 percent...."

    Lois Neis

  • "...I felt very comfortable and only saw him 3 times before almost all my pain was gone..."

    Katie Steele

  • "...He really knows what it takes to help feel better and live life to the fullest!"

    Annamaria Bliven

  • "...I was referred to Dr. Eric and after my first visit I had full motion back in my shoulder, after the 2nd visit I had no pain and could throw a golf ball. I highly recommend Dr. Eric..."

    Paul Brooks

  • "...My experience has been nothing short of amazing as I have begun to roll back the effects of 10+ years with a connective tissue autoimmune disorder..."

    Kathleen Harwood

  • "...Just after a few adjustments, I had noticed a huge difference from the way I was feeling. He is truly a caring man and is all about getting the patient better..."

    Lilly Blumer

  • "...He helped me get through a hip injury during my Ironman training and also gave me a list of stretches and exercises to do to prevent it from happening again..."

    Kenny Haferkorn

  • "...I have recommended Dr. Eric to family and friends. I can't thank him enough for his compassion and desire to see that I have the quality of life that I have always wanted."

    Karie Nafzger

Address

7818 Big Sky Dr
Suite 215
Madison, WI 53719

PHONE

608-203-9272

Hours

Monday - Saturday: 9am - 6pm
Other Hours Available by Appointment

Follow Us

© 2019 All rights reserved | Powered by DIGITAL FITNESS | Sitemap |

TOP Cleantalk Pixel